SKU: M048  / 
    CAS Number: 75731-43-0

    Marcfortine A

    $306.50 - $1,072.00

    Marcfortine A is an indole alkaloid originally isolated from Penicillin roqueforti.  It has nematocidal activity.  The marcfortines are structurally related to paraherquamides.

    Marcfortine A is soluble in ethanol, methanol, DMF or DMSO but has poor water solubility.

    Mechanism of Action The marcfortines are thought to act by blocking cholinergic neuromuscular transmission.
    Insect Biology Applications Marcfortine A has activity against the gastrointestinal nematode Haemonchus contortus (Zinser et al, 2002).
    Molecular Formula C28H35N3O4
    Spectrum Marcfortines have broad-spectrum anthelmintic activity that includes drug-resistant strains of nematodes.

    Blanchflower SE et al (1993)  Further novel metabolites of the paraherquamide family. J. Antibiot. 46:1355

    Capon RJ et al  (2003)  Aspergillicins A-E: Five novel depsipeptides from the marine-derived fungus Aspergillus carneus. Org. Biomol. Chem. 1:1856

    Johnson SS (2004)  Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs.  J Vet Pharmacol Ther. 27(3):169-181 PMID 15189303

    Kuo MS et al (1996)  Biosynthesis of Marcfortine A.  J. Antibiot. 49(10):1006-1013

    Zinser EW (2002)  Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals. J. Vet. Pharmacol. Ther. 25(4):241-250  PMID 12213111