Linezolid is an oxazolidinone antibiotic and is effective against Gram-positive bacteria including certain strains of methicillin-resistant Staphylococcus aureus (MRSA).
Mechanism of Action | Linezolid inhibits protein synthesis by binding to the 50S ribosomal subunit (23S rRNA) which prevents formation of the 70S initiation complex thus inhibiting mRNA translation. It is also a monoamine oxidase inhibitor displaying nonselective, reversible binding. |
Spectrum | Effective for Gram-positive bacteria including certain strains of MRSA |
Eukaryotic Cell Culture Applications | Linezolid inhibits cytokine production from human peripheral blood monocytes in a dose-dependent manner. Linezolid was found to modify the acute phase inflammatory response. Linezolid inhibits cytokine production from human peripheral blood monocytes in a dose-dependent manner (Garcia-Roca et al, 2006). |
Molecular Formula | C16H20FN3O4 |
References |
Ament PW (2002) Linezolid: Its role in the treatment of Gram-Positive, drug-resistant bacterial infections. Amer. Family Phys. 65(4):663-671
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