SKU: E008  / 
    CAS Number: 153773-82-1

    Ertapenem Sodium, EvoPure®

    ฿15,127.20

    Ertapenem Sodium, EvoPure® is a highly purified form of Ertapenem Sodium. It is a broad-spectrum carbapenem that interferes with peptidoglycan synthesis.

    Mechanism of Action β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues, providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid-encoded β-lactamases.
    Spectrum Ertapenem Sodium has broad-spectrum activity targeting a wide spectrum of aerobic and anaerobic Gram-positive and Gram-negative bacteria.
    Microbiology Applications Ertapenem Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

    Representative MIC values include:
    • Staphylococcus aureus: 0.12 µg/mL – >16 µg/mL
    • Escherichia coli: ≤ 0.008 - 0.5 µg/mL

    For a representative list of Ertapenem MIC values, click here.

    It is active against cephalosporin-resistant enteric organisms producing Extended-Spectrum Beta-Lactamases (ESBLs) and penicillin-resistant Streptococcus pneumoniae. It has restricted activity against nosocomial pathogens including Pseudomonas aeruginosa, Acinetobacter species, methicillin-resistant staphylococci and enterococci.

    Molecular Formula C22H24N3O7S • Na
    References

    Cunha BA (2002)  Ertapenem.  A review of its microbiologic, pharmacokinetic and clinical aspects. Drugs Toay (Barc) 38(3):195-213  PMID 12532175

    Hammond ML (2004)  Ertapenem: A group 1 carbapenem with distinct antibacterial and pharmacological properties. J. Antimcrob. Chemother 53(2):7-9

    Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103:51