SKU: D004  / 
    CAS Number: 364622-82-2 (hydrate); 148016-81-3 (anhydrous)

    Doripenem hydrate

    Doripenem hydrate is a β-lactam antibiotic of the carbapenem class.  It is effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae, a microbe resistant to many first line beta-lactam antibiotics and certain cephalosporins.  Doripenem hydrate is sparingly soluble in aqueous solution.

    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases; however, carbapenems, including doripenem, are highly resistant to β-lactamases.
    SpectrumDoripenem hydrate is a broad spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa.
    Microbiology ApplicationsDoripenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Bacteroides fragilis 0.125 µg/mL – 8 µg/mL
    • Pseudomonas aeruginosa 8 µg/mL - 32 µg/mL
    • For a complete list of doripenem MIC values, click here.

    Molecular FormulaC15H24N4O6S2•H2O
    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

    MICBacteroides distasonis| 0.25 - 1|| Bacteroides fragilis| 0.125 - 16|| Bacteroides ovatus| 0.25 - 4|| Bacteroides thetaiotaomicron| 0.12 - 2|| Bacteroides vulgatus| 0.125 - 1|| Bilophila wadsworthia| 0.03 - 0.12|| Burkholderia cepacia| 0.5 - 256|| Clostridium bifermentans| 0.06 - 0.125|| Clostridium cadaveris| 0.03|| Clostridium clostridioforme| 1|| Clostridium difficile| 0.5 - 4|| Clostridium innocuum| 1|| Clostridium paraputrificum| 0.25|| Clostridium perfringens| ≤0.016 - 0.06|| Clostridium ramosum| 0.5 - 1|| Clostridium sordellii| 0.03|| Clostridium spp.| 0.03 - 4|| Finegoldia magna| 0.06 - 0.125|| Fusobacterium mortiferum| 0.125 - 1|| Fusobacterium necrophorum| ≤0.016 - 0.25|| Fusobacterium nucleatum| ≤0.016 - 0.03|| Fusobacterium spp.| 0.03 - 1|| Fusobacterium varium| 0.06 - 1|| Gram-Positive Anaerobic Cocci| 0.03 - 0.25|| Micromonas micros| ≤0.016 - 0.125|| Nonsporing gram-positive rods| 0.03 - 8|| Peptoniphilus asaccharolyticus| ≤0.016 - 0.125|| Peptostreptococcus anaerobius| 0.125 - 2|| Porphyromonas asaccharolytica| ≤0.016 - 0.03|| Porphyromonas gingivalis| ≤0.016|| Porphyromonas levii | 0.03|| Porphyromonas spp.| 0.03 - 4|| Prevotella bivia| 0.03 - 4|| Prevotella buccae| 0.06 - 0.125|| Prevotella corporis | 0.03 - 0.06|| Prevotella denticola| ≤0.016 - 0.25|| Prevotella disiens| 0.03 - 4|| Prevotella intermedia| ≤0.016 - 0.125|| Prevotella melaninogenica| ≤0.016 - 0.25|| Prevotella nigrescens| 0.03 - 0.062|| Prevotella oris| 0.03 - 0.5|| Prevotella spp.| 0.03 - 0.25|| Pseudomonas aeruginosa| 0.06 - 512|| Sutterella wadsworthensis| 0.06 - 32||