SKU: C050  / 
    CAS Number: 117467-28-4

    Cefditoren Pivoxil


    Cefditoren pivoxil is a third-generation cephalosporin antibiotic.

    TOKU-E offers three forms of cefditoren:

    Mechanism of Action Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
    Spectrum Cefditoren is a broad spectrum antibiotic commonly used against bacteria responsible for community acquired pneumonia and pharyngitis
    Microbiology Applications Cefditoren pivoxil can be used to study antibiotic effects against group A Streptococcus and other microbes responsible for phayrngitis.
    Molecular Formula C25H28N6O7S3
    Impurities Single Impurity: ≤0.1%
    Total Impurities: ≤5.0%

    Poveda, J. L., et al. "Cefditoren Pivoxil: A New Oral Cephalosporin for Skin, Soft Tissue and Respiratory Tract Infections." Medline 19.3 (n.d.): Web. 27 Aug. 2012.

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    MIC Haemophilus influenzae (TUM8)| 2|| Streptococcus pneumonia | 0.25 - 16||