Antimycin A3 is an homolog of the Antimycin complex (syn: Antimycin A). Antimycin A3 is one of four closely related structures in the mixture (others include Antimycin A1, A2 and A4). First isolated in 1958 from Streptomyces blastimyceticus and co-produced with Antimycin A4, Antimycin A3 is a more polar analog of A1 and A2.
Antimycin A3 has broad biological activity as an antifungal, anthelmintic (antiparasitic), insecticidal, antiviral and antitumor agent. Lack of availability of the individual Antimycin components has hindered greater understanding of the common and unique molecular targets of the components of the Antimycin complex.
The Antimycin complex chemical structure consists of an acyl- and alkylsubstituted dilactone ring linked via an amide bond to 3-formamidosalicylic acid.
Antimycin A3 is soluble in ethanol, methanol, DMF and DMSO.
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