• OP-145

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SKU: O012

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Description
OP-145 is a synthetic antimicrobial peptide (AMP) similar to the human cathelicidin LL-37. OP-145 consists of 24 amino acids and has demonstrated antibacterial and cytotoxic properties.

    CAS Number

    Not Established

    Molecular Formula

    C142H246N46O31

    Molecular Weight

    3093.762

    Mechanism of Action

    OP-145 interacts with phospholipids in bacterial and mammalian cell membranes leading to membrane thinning and permeabilization.

    Spectrum

    OP-145 is active against Staphylococcus aureus at 0.8-1.6 ┬ÁM and may be effective against other Gram-positive bacteria.

Specifications

    Appearance

    Off white to light yellow powder

References

    References

    Malanovic, Nermina, Regina Leber, Maria Schmuck, Manfred Kriechbaum, Robert A. Cordfunke, Jan W. Drijfhout, Anna De Breij, Peter H. Nibbering, Dagmar Kolb, and Karl Lohner. "Phospholipid-driven Differences Determine the Action of the Synthetic Antimicrobial Peptide OP-145 on Gram-positive Bacterial and Mammalian Membrane Model Systems." Biochimica Et Biophysica Acta (BBA) - Biomembranes 1848.10 (2015): 2437-447.

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