OP-145 is a synthetic antimicrobial peptide (AMP) similar to the human cathelicidin LL-37. OP-145 consists of 24 amino acids and has demonstrated antibacterial and cytotoxic properties.
|Mechanism of Action||OP-145 interacts with phospholipids in bacterial and mammalian cell membranes leading to membrane thinning and permeabilization.|
|Spectrum||OP-145 is active against Staphylococcus aureus at 0.8-1.6 µM and may be effective against other Gram-positive bacteria.|
|References||Malanovic, Nermina, Regina Leber, Maria Schmuck, Manfred Kriechbaum, Robert A. Cordfunke, Jan W. Drijfhout, Anna De Breij, Peter H. Nibbering, Dagmar Kolb, and Karl Lohner. "Phospholipid-driven Differences Determine the Action of the Synthetic Antimicrobial Peptide OP-145 on Gram-positive Bacterial and Mammalian Membrane Model Systems." Biochimica Et Biophysica Acta (BBA) - Biomembranes 1848.10 (2015): 2437-447.|