• Meropenem with sodium carbonate packaged and labeled.

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SKU: M028

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Description

Meropenem with sodium carbonate is a salt form of meropenem; a β-lactam antibiotic in the carbapenem class. Meropenem with sodium carbonate is very soluble in water at approximatley 112 mg/mL.

    Molecular Formula

    C17H25N3O5S • Na2CO3

    Molecular Weight

    466.46

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.5000

    Spectrum

    Meropenem has a broad spectrum of activity and has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line beta-lactam antibiotics and certain cephalosporins.

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    pH

    7.3 - 8.3

    Assay

    (Dried basis, Meropenem) Not less than 78.0%

    Loss on Drying

    9.0% - 12.0%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 10ppm

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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