• Meropenem with sodium carbonate packaged and labeled.

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SKU: M028

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Description

Meropenem with sodium carbonate is a salt form of Meropenem, which is a β-lactam antibiotic in the carbapenem class, which targets the bacterial cell wall. Meropenem has found utility against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae  that are resistant to many β-lactam antibiotics and certain cephalosporins. Meropenem with sodium carbonate is very soluble in water.

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  • Meropenem, USP (M002)

    Molecular Formula

    C17H25N3O5S • Na2CO3

    Molecular Weight

    466.46

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.5000

    Spectrum

    Meropenem has a broad spectrum of activity and has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line beta-lactam antibiotics and certain cephalosporins.

Applications

    Microbiology Applications

    Meropenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Meropenem has also shown high potency against high-resistant superbug strains.Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:

      • Staphylococcus epidermidis 0.06 µg/mL - 16 µg/mL
      • Neisseria meningitis 0.002 µg/mL – 0.03 µg/mL
      • For a complete list of Meropenem MIC values, click here.

    Media Supplements

    Meropenem can be used as a selective agent in several types of isolation media:

    VRE Medium - VRE Selective Supplement

    Plant Biology Applications

    Meropenem can be used to suppress the overgrowth of Agrobacterium in tobacco, tomato, and rice transformation, with 25 mg/L suppressing outgrowth (Ogawa and Mii , 2007). 

    Meropenem suppressed growth of Agrobacterium during transformation of Phalaenopsis at 5 mg/L and had no phytotoxic effect on the cells themselves (Sjahril and Mii, 2005).

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    pH

    7.3 - 8.3

    Assay

    (Dried basis, Meropenem) Not less than 78.0%

    Loss on Drying

    9.0% - 12.0%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 10ppm

References

    References

    Guzmán F(2008)  Beta lactams antibiotics (penicillins and cephalosporins) mechanism of action. Med. Pharmacol.  Pharmacology Corner, 29 Nov. 2008

    Ogawa Ya and Mii M (2007)  Meropenem and moxalactam: Novel B-lactam antibiotics for efficient Agrobacterium-mediated transformation. 172(3):564-572

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103:51

    Sjahril R and Masahiro Mii M (2006) High-efficiency Agrobacterium-mediated transformation of Phalaenopsis using meropenem, a novel antibiotic to eliminate Agrobacterium. J. Hort. Sci and Biotechnol 8(3):458-464

    Yang Y, Bhachech N and Bush K (1995)  Biochemical comparison of imipenem, meropenem and biapenem: Permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases. J. Antimicrob.  Chemother. 35(1):75-84

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