• Meropenem, USP packaged and labeled.

click on thumbnail to zoom
SKU: M002

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Meropenem is a β-lactam antibiotic in the carbapenem class and is sparingly soluble in aqueous solution (5.63 mg/mL). Meropenem has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line beta-lactam antibiotics and certain cephalosporins.

    CAS Number

    119478-56-7

    Molecular Formula

    C17H25N3O5S • 3H2O

    Molecular Weight

    437.52

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Meropenem is a broad spectrum antibiotic targeting a wide range of bacteria especially those which cause meningitis.

Applications

    Microbiology Applications

    Meropenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Meropenem has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Staphylococcus epidermidis 0.06 µg/mL - 16 µg/mL
    • Neisseria meningitis 0.002 µg/mL – 0.03 µg/mL
    • For a complete list of meropenem MIC values, click here.

    Media Supplements

    Meropenem can be used as a selective agent in several types of isolation media:

    VRE Medium - VRE Selective Supplement

Specifications

    Form

    Powder

    Appearance

    Almost white or yellowish crystalline powder

    Source

    Synthetic

    Impurity Profile

    Chromotographic Purity:
    Any two major impurities: Not more than 0.3%
    Single impurity: Not more than 0.1%
    Total impurities: Not more than 0.3%

    Water Content (Karl Fisher)

    11.4-13.4%

    pH

    4.0 - 6.0

    Optical Rotation

    -17.0° to -21.0°

    Assay

    (On Dried Basis): 98.0 - 101.0%

    Residue On Ignition

    ≤ 0.1%

    Heavy Metals

    ≤ 10ppm

    Residual Solvents

    Acetone: ≤ 0.05%

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

Other Items In This Category