• Meropenem, USP packaged and labeled.

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SKU: M002

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Description

Meropenem is a β-lactam antibiotic in the carbapenem class, and targets the bacterial cell wall.   It has found utility against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae  that are resistant to many first line β-lactam antibiotics and certain cephalosporins.  Meropenem is sparingly soluble in aqueous solution.

We also offer:

  • Meropenem with sodium carbonate (M028) 

    CAS Number

    119478-56-7

    Molecular Formula

    C17H25N3O5S • 3H2O

    Molecular Weight

    437.52

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Meropenem is a broad-spectrum antibiotic targeting a wide range of bacteria especially those causing meningitis.

Applications

    Microbiology Applications

    Meropenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Meropenem has also shown high potency against high-resistant superbug strains.Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:

    • Staphylococcus epidermidis 0.06 µg/mL - 16 µg/mL
    • Neisseria meningitis 0.002 µg/mL – 0.03 µg/mL
    • For a complete list of Meropenem MIC values, click here.

    Media Supplements

    Meropenem can be used as a selective agent in several types of isolation media:

    VRE Medium - VRE Selective Supplement

    Plant Biology Applications

    Meropenem can be used to suppress the overgrowth of Agrobacterium in tobacco, tomato, and rice transformation, with 25 mg/L suppressing outgrowth (Ogawa and Mii , 2007).

    Meropenem suppressed growth of Agrobacterium during transformation of Phalaenopsis at 5 mg/L and had no phytotoxic effect on the cells themselves (Sjahril and Mii, 2005).

Specifications

    Form

    Powder

    Appearance

    almost white or yellowish crystalline powder

    Source

    Synthetic

    Impurity Profile

    Chromotographic Purity:
    Any two major impurities: Not more than 0.3%
    Single impurity: Not more than 0.1%
    Total impurities: Not more than 0.3%

    Water Content (Karl Fischer)

    11.4-13.4%

    pH

    4.0 - 6.0

    Optical Rotation

    -17.0° to -21.0°

    Assay

    (On Dried Basis): 98.0 - 101.0%

    Residue On Ignition

    ≤ 0.1%

    Heavy Metals

    ≤ 10ppm

    Residual Solvents

    Acetone: ≤ 0.05%

References

    References

    Guzmán F(2008)  Beta lactams antibiotics (penicillins and cephalosporins) mechanism of action. Med. Pharmacol.  Pharmacology Corner, 29 Nov. 2008

    Ogawa Ya and Mii M (2007)  Meropenem and moxalactam: Novel B-lactam antibiotics for efficient Agrobacterium-mediated transformation. 172(3):564-572

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103:51

    Sjahril R and Masahiro Mii M (2006) High-efficiency Agrobacterium-mediated transformation of Phalaenopsis using meropenem, a novel antibiotic to eliminate Agrobacterium. J. Hort. Sci and Biotechnol 8(3):458-464

    Yang Y, Bhachech N and Bush K (1995)  Biochemical comparison of imipenem, meropenem and biapenem: Permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases. J. Antimicrob.  Chemother. 35(1):75-84

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