• Meropenem, USP packaged and labeled.

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SKU: M002

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Meropenem is a β-lactam antibiotic in the carbapenem class and is sparingly soluble in aqueous solution (5.63 mg/mL). Meropenem has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line beta-lactam antibiotics and certain cephalosporins.

    CAS Number


    Molecular Formula

    C17H25N3O5S • 3H2O

    Molecular Weight


    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, meropenem is highly resistant to the degradative effects of β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code



    Meropenem is a broad spectrum antibiotic targeting a wide range of bacteria especially those which cause meningitis.


    Microbiology Applications

    Meropenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Meropenem has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Staphylococcus epidermidis 0.06 µg/mL - 16 µg/mL
    • Neisseria meningitis 0.002 µg/mL – 0.03 µg/mL
    • For a complete list of meropenem MIC values, click here.

    Media Supplements

    Meropenem can be used as a selective agent in several types of isolation media:

    VRE Medium - VRE Selective Supplement





    Almost white or yellowish crystalline powder



    Impurity Profile

    Chromotographic Purity:
    Any two major impurities: Not more than 0.3%
    Single impurity: Not more than 0.1%
    Total impurities: Not more than 0.3%

    Water Content (Karl Fischer)



    4.0 - 6.0

    Optical Rotation

    -17.0° to -21.0°


    (On Dried Basis): 98.0 - 101.0%

    Residue On Ignition

    ≤ 0.1%

    Heavy Metals

    ≤ 10ppm

    Residual Solvents

    Acetone: ≤ 0.05%



    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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