SKU: F019

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Description

Fusidic acid is a bacteriostatic steroid antibiotic which targets protein synthesis in Gram-positive bacteria.

    CAS Number

    6990-06-3

    Molecular Formula

    C31H48O6

    Molecular Weight

    516.72

    Mechanism of Action

    Fusidic acid inhibits protein synthesis by preventing translocation by inhibiting ribosomal elongation factor G.

    Storage Conditions

    2-8°C

    Spectrum

    Fusidic acid targets Gram-positive bacteria namely those which cause skin infections.

Applications

    Microbiology Applications

    Fusidic acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Methicillin resistant Staphylococcus aureus (MRSA) 0.12 µg/mL - 1.0 µg/mL
    • Streptococcus epidermidis 0.25 µg/mL
    For a complete list of fusidic acid MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or almost white, crystalline powder

    Source

    Fusidium coccineum

    Impurity Profile

    Impurity A| ent-(24SR,17Z)-16a-(acetoxy)-3b,11b,24,25-tetrahydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholest-17(20)-en-21-oic acid (24,25-dihydroxyfusidic acid)|||| Impurity C| ent-(17Z) -3b,11b-dihydroxy-17-[(6S)-6-(1-Hydroxy-1-methylethyl)-2-oxodihydro-2H-pyran-3(4H)-ylidene]-4b,8,14-trimethyl-18-nor-5b,10a-androstan-16a-yl acetate ((24R)-24,25-dihydroxyfusidic acid 21,24-lactone)|||| Impurity D| ent-(17Z) -3b,11b-dihydroxy-17-[(6R)-6-(1-hydroxy-1-methylethyl)-2-oxodihydro-2H-pyran-3(4H)-ylidene]-4b,8,14-trimethyl-18-nor-5b,10a-androstan-16a-yl acetate ((24S)-24,25-dihydroxyfusidic acid 21,24-lactone|||| Impurity E| ent-(17Z) -16a-(acetyloxy)-3b,11b,27-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21-oic acid (27-hydroxyfusidic acid)|||| Impurity F| ent-(17Z) -16a-(acetyloxy)-3b,11b,27-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21-oic acid (27-hydroxyfusidic acid)|||| Impurity K| ent-(17Z) -3b,11b,16a-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21,16-lactone(16-deacetylfusidic acid 21,16-lactone)|||| Impurity UN1| Fusidate Sodium||||

    Water Content (Karl Fisher)

    1.4% - 2.0%

    Assay

    (Anhydrous) 97.5% - 101.0%

References

    References

    Collignon, Peter, and John Turnidge. "Fusidic Acid in Vitro Activity." International Journal of Antimicrobial Agents 12.2 (1999): 45-58. Ncbi.gov. Web. 6 Dec. 2012.

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