• Clavulanic acid potassium w/ cellulose (1:1) packaged and labeled.

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SKU: C065

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Description

Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Antibiotics can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.

    CAS Number

    61177-45-5

    Molecular Formula

    Mixture

    Molecular Weight

    Mixture

    Mechanism of Action

    Like other β-lactam antibiotics, the chemical structure of clavulanic acid contains a β-lactam ring allowing it to act as a β-lactamase inhibitor. By forming a covalent bond with inhibiting β-lactamase enzymes, clavulanate allows β-lactam antibiotics to bind and inhibit PBPs (penicillin binding protein) without interference from degredative enzymes.

    Tariff Code

    2933.79.8500

Specifications

    Form

    Powder

    Appearance

    White or almost white powder

    Source

    Mixture

    Water Content (Karl Fisher)

    ≤2.5%

    Absorbance

    ≤0.4 at 278nm

    pH

    4.8-8.0

    Assay

    48.0-53.5% (on dried basis) (Clavulanic acid potassium)

    Impurities

    n-Butanol: ≤5000ppm
    Impurity E: ≤1.0%
    Impurity G: ≤1.0%
    Any other impurity: ≤0.2%
    Total Impurities: ≤2.0%

    Residual Solvents

    Acetone: ≤5000ppm

References

    References

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

    Wise, R., J. M. Andrews, and K. A. Bedford. "In Vitro Study of Clavulanic Acid in Combination with Penicillin, Amoxycillin, and Carbenicillin." Antimicrobial Agents and Chemotherapy 13.3 (1978): 389-93. Ncbi.gov. Web. 2 Nov. 2012.

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