• Clavulanate Potassium

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SKU: C232

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Description
Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of βlactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.

    CAS Number

    61177-45-5

    Molecular Formula

    C8H8NO5K

    Molecular Weight

    237.3

    Storage Conditions

    -20┬░C

Specifications

    Form

    Powder

    Appearance

    White to off White Powder

    Source

    Streptomyces sp.

References

    References

    Clavulanic acid and its derivatives. Structure elucidation of clavulanic acid and the preparation of dihydroclavulanic acid, isoclavulanic acid, esters and related oxidation products. Brown A. G. et al., J. Chem. Soc. Perkin Trans. I 1984, 635 Naturally occurring beta-lactamase inhibitors with antibacterial activity. Brown A. G. J. Antibiot. 1976, 29, 668.

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