SKU: C205

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Description
Cecropin A is an antimicrobial peptide originally isolated from insects, but now believed to be naturally produced and found in a large variety of organisms including mammals. It has garnered a lot of interest for its broad-spectrum antiparasitic and antibacterial activities. It is also active against fungi, and has cytotoxic effects on cancer cell lines. It is common to find this peptide as part of a fusion protein or the beginnings of a derived series of antimicrobial peptides in new antimicrobial drug research.

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    CAS Number

    80451-04-3

    Molecular Formula

    C184H313N53O46

    Molecular Weight

    4003.78

    Mechanism of Action

    The antibacterial mode of action for Cecropins is pore-formation based, in which an antimicrobial peptide inserts itself into the bacterial membrane and allows ions to flow freely through, resulting in cell depolarization and death.

References

    References

    Cerón, J. M., Contreras-Moreno, J., Puertollano, E., Cienfuegos, G. Á, Puertollano, M. A., & Pablo, M. A. (2010). The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides, 31(8), 1494-1503. doi:10.1016/j.peptides.2010.05.008

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