Antibacterials

Vancomycin

Vancomycin is a glycopeptide antibiotic derived from Streptomyces orientalis that was discovered in 1953 from a soil sample found in Borneo. It is effective against gram-positive bacteria such as Staphylococcus aureus and is used in studies of...

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Norfloxacin

Norfloxacin is a first-generation synthetic fluoroquinolone antibiotic. Mechanism of Action Norfloxacin indirectly inhibits DNA gyrase by binding to nearby DNA substrate. DNA gyrase is an essential DNA replication enzyme which reduces DNA strain...

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Polymyxin B Sulfate, USP

Polymyxin B Sulfate, USP is a polypeptide antibiotic mixture composed of Polymyxins B1, B2, and B3 fractions, with B1 and B2 fractions comprising the majority of the mixture. Polymyxin B components are structurally identical with the exception of a...

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Nalidixic Acid

Nalidixic Acid is a synthetic 1,8-naphthyridone antibiotic similar in structure and mechanism to quinolones.  It can be used as a tool to study bacterial division regulation.  The compound can also be used in the RADAR assay, a method for...

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Lincomycin Hydrochloride, USP

Lincomycin Hydrochloride is the hydrochloride form of Lincomycin, provided as the monohydrate. Lincomycin is a naturally occurring lincosamide isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a...

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Fosfomycin Sodium

Fosfomycin Sodium is broad-spectrum phosphoenolpyruvate analog antibiotic.  It has a chemically unique structure unlike any other antibacterial agent.  Fosfomycin has been found to have an immunomodulatory effect on human B-cell activation...

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Ceftazidime Pentahydrate

Ceftazidime Pentahydrate is a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis.  Patented in 1979 by Glaxo Group, Ceftazidime came into commercial use in 1984.  Ceftazidime is...

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Colistin Sulfate, USP

Colistin Sulfate, USP (syn: polymyxin E) is a cationic, cyclic polypeptide antibiotic belonging to the polymyxin family. It is a natural product discovered in 1949 that is nonribosomally synthesized by Bacillus polymyxa subspecies colistinus...

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Colistin Sodium Methanesulfonate

Colistin Sodium Methanesulfonate is considered an inactive prodrug of colistin, which means it is inactive until converted into colistin by cellular enzymes. It is prepared by the reaction of colistin with formaldehyde, followed by sodium bisulfate. It...

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Siomycin A

Siomycin is a macrocyclic thiopeptide antibiotic with potent and selective antibacterial activity first isolated from the fermentation product of Streptomyces sioyaensis by Nishimura in 1959. This member of the thiostrepton family is a potent inhibitor...

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Clindamycin Phosphate

Clindamycin Phosphate (Clindamycin-2-phosphate) is a broad-spectrum antibiotic and antiparasitic agent.  It is a semi-synthetic derivative of Lincomycin, a natural lincosamide from Streptomyces lincolnensis.  Clindamycin Phosphate is freely...

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Cefotetan

Cefotetan is a cephamycin antibiotic grouped with the second-generation cephalosporins. TOKU-E offers two forms of cefotetan: Cefotetan (C012) Cefotetan Disodium (C117) Cefotetan is sparingly soluble in water (0.51 mg/mL) and cefotetan disodium is...

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