Antibacterials

Galbinic Acid

Galbinic Acid (α-acetylsalazinic acid) is a depsidone isolated from the lichen, Usnea undulata. The structure of galbinic acid was elucidated by Elix, Australian National University in 1975. Galbinic Acid is moderately active against Gram-positive...

View Details

Leoidin

Leoidin is a metabolite of the lichen, Lecanora gangleoides, first published in 1986 and recently reported as an inhibitor ofprotein synthesis in Pseudomonas aeruginosa. Leoidin is bacteriostatic, targeting PheRS. Leoidin is a weak inhibitor of human...

View Details

Manumycin A

Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has...

View Details

Novobiocic Acid

Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial...

View Details

Pluviatolide

Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile, by Taylor and Ritchie in 1970. More recently, Pluviatolide and the related hinokinin were reported as metabolites of the vine, Aristolochia...

View Details

Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

View Details

Radicinol

Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, Radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. ...

View Details

Roccellic Acid

Roccellic Acid is a secondary metabolite and methyldodecylsuccinic acid isolated from lichen Roccella spp. over 150 years ago, with the structure fully elucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus...

View Details

Sparsomycin

Sparsomycin is a nucleotide analogue produced by Streptomyces sparsogenes isolated by researchers at Upjohn (now Pfizer) in 1962. Sparsomycin binds to the 50S ribosomal subunit and inhibits protein synthesis via peptidyl transferase inhibition. ...

View Details

Sartorypyrone B

Sartorypyrone B is a pentacyclic meroterpenoid metabolite isolated from Aspergillus (syn. Neosartorya) species. Whilesartorypyrone B possesses no antibiotic activity against S. aureus, P. aeruginosa. B. subtilis and E. coli, it is nonethelessscapable of...

View Details

Streptimidone

Streptimidone (protomycin) is a glutarimide antibiotic isolated from Streptomyces spp. first reported in 1959. Streptimidone is active against a wide spectrum of fungi and protozoans, including Entamoeba hystolica in vitro and in vivo. Streptimidone also...

View Details

Terrelulamide A

Terrelulamide A is a rare lumazine pseudo-tripeptide metabolite isolated from a marine strain of Aspergillus terreus byresearchers at Seoul National University, Korea reported in 2015. Terrelulamide A is reported as having metabolic effects and improves...

View Details