Antibacterials

Aspergillin PZ

Aspergillin PZ is an isoindole metabolite isolated from Aspergillus awarori by activity-guided fractionation and purification. Aspergillin PZ adversely affects the hyphae and spores of P. oryzae, a nitrogen-fixing bacterium. Aspergillin PZ has weak...

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Ascochin

Ascochin is isolated from the endophytic fungus, Ascochyta species with antifungal, antibacterial and phytotoxic properties. Molecular Formula  C12H10O5 References Krohn K et al (2007)  Bioactive natural products from the endophytic...

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Artemisin

Artemisinin is a sesquiterpene lactone isolated from the aerial parts of Artemisia annua L.. Artemisin is best known for its activity against the malaria parasite including resistant strains, but also has antitumor, immunomodulatory and...

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Aranciamycin A

Aranciamycin A is an anthracycline bearing a methyl-L-rhamnose sugar in the 2-O position. Aranciamycin A has antitumor and Gram positive antibiotic activity and is a potent inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10-​7M...

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Aquastatin A

Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of...

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Apramycin

Apramycin is a structurally unique broad-spectrum aminoglycoside with a bicyclic sugar moiety and a monosubstituted deoxystreptamineactive. Apramycin inhibits the translocation step of bacterial protein synthesis and induces translation errors. Apramycin...

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Ansamitocin P3

Ansamitocins, a new group of ansamycin antibiotics with potent antitumor activity, were first reported in the journal Nature in 1977 by researchers from Takeda Chemical Industries. Anisomitocin P3 is the 3-O-methylpropanoyl derivative of maytansinol...

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Anandamide

Anandamide is an endogenous ligand for the cannabinoid receptor. Anandamide activates receptor-​mediated signal transduction and stimulates arachidonic acid and intracellular calcium release in both CHOm5 and CHO-​HCR cells. More recent research has...

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Anagyrine

Anagyrine is a teratogenic quinolizidine alkaloid found in Lupinus sp. which undergoes metabolism to a piperidine that causes crooked calf syndrome. Anagyrine, but not lupanine or sparteine, directly desensitize nicotinic acetylcholine receptors (nAChR)...

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Amycolatopsin C

Amycolatopsin C is a glycosylated polyketide isolated by Microbial Screening Technologies from Amycolotopsis sp.. The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the 6-methyl...

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Amycolatopsin B

Amycolatopsin B is a glycosylated polyketide isolated by Microbial Screening Technologies. The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the 6-methyl position, selectively...

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Amycolatopsin A

Amycolatopsin A is a glycosylated polyketide isolated by Microbial Screening Technologies from Amycolotopsis sp.  The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the...

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