Antimicrobials

Pepstatin A

Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells...

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Pentalenic acid

Pentalenic acid has been isolated from many Streptomyces sp. as a co-metabolite of the sesquiterpenoid antibiotic pentalenolactone and related natural products. Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family...

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Penipurdin A

Penipurdin A was first reported as an orange-red anthraquinone produced by soil-derived Penicillium purpurogenum by Li and co-workers from the Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong, China in 2015...

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Palmarumycin C3

The palmarumycins are fungal metabolites isolated from Coniothyrium and Sphaeropsidales sp. with antifungal, antibacterial, antitumor and herbicidal properties. Palmarumycin C3 is a yellow-green pigment which inhibits Ras farnesyl-protein...

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Pactamycin

Pactamycin (syn: Pactacin) is a unique type of highly-substituted aminocyclitol produced by Streptomyces sp. which is a potent inhibitor of translation in eukaryotes, bacteria and archaea, active against Gram-positive and Gram-negative bacteria. ...

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Oosporein

Oosporein is a purple-red pigment published as a metabolite of Acremonium sp. in 1959. Oosporein has antibacterial, antiviral and antifungal activity. Oosporein is produced by the entomopathogenic fungus Beauveria bassiana after host death, acting to...

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Nikkomycin Z

Nikkomycin Z is a natural product, a nucleoside-type antibiotic isolated from Steptomyces tendae in the mid-1970s. Nikkomycin Z has potent narrow-spectrum activity against some fungi, including Rhizopus cirdinans, Colletrotrichum trifolii and Botrytis...

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Neosartoricin B

Neosartoricin B was produced biosynthetically in 2013 by Tang and colleagues from UCLA USA by selecting the gene cluster for neosartoricin that is homologous to a conserved cluster among dermatophytes of the Trichophyton and Arthroderma genera. When...

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Neosartoricin

Neosartoricin is a carbotricyclic metabolite produced by Aspergillus fumigatus and Neosartorya fischeri following activation of their polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters, reported by Tang and...

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Nanangenine H

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine H is an acylated drimane which is a putative biosynthetic intermediate of the higher nanagenines...

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Nanangenine G

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine G is an acylated drimane which is a putative biosynthetic intermediate of the higher...

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Nanangenine F

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine F is an acylated drimane and putative biosynthetic intermediate of the higher nanangenines...

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