Antimicrobials

Lupanine

Lupanine is a tetracyclic quinolizidine isolated from lupins. Lupanine inhibits the growth of phytopathogenic fungi, reducing the germination of conidia of powdery mildew and the further development to appressoria with an IC50 of 1-5 mmol/L. Lupanine...

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Linearmycin A

Linearmycin A is novel linear polyene antibiotic isolated from mycelial extracts of Streptomyces sp. Linearmycin A and B have similar, long linear structures terminating with amino and carboxylic acid groups. The carboxylic acid terminal of linearmycin A...

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Kynurenic Acid

Kynurenic acid is an endogenous tryptophan metabolite of mammals and a constituent of Ephedra transitoria. Kynurenic acid is an antagonist of N-​methyl-​D-​aspartate (NMDA) and α-​7 nicotinic acetylcholine (α7nACh) receptors and scavenges...

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Indole-3-propionic acid

Indole-3-propionic acid is a tryptophan metabolite long recognised as a plant growth regulator. Indole-3-propionic acid is produced by microbiota in the human gut, including Clostridium sporogenes. Indole-3-propionic acid is a potent antioxidant and free...

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Indole-3-carboxylic acid

Indole-3-carboxylic acid is a tryptophan metabolite produced by microbiota in the human gut. Indole-3-carboxylic acid isolated from Streptomyces sp. is active against Gram positive bacteria, yeast and fungi. Indole-3-carboxylic acid induces resistance in...

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Indole-3-carboxaldehyde

Indole-3-carboxaldehyde is an endogenous metabolite of plants and is produced in humans by the metabolism of L-tryptophan in Lactobacillus and other gastrointestinal bacteria. Indole-3-carboxaldehyde is an immunomodulator, acting as an agonist of the...

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Hodgkinsine trimethyl triiodide

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. There is not much information on the biological activity of hodgkinsine trimethyliodide due to lack of availability of the...

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Hodgkinsine B

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodgkinsine B is the enantiomer of hodgkinsine. There is scant information on the biological activity of hodgkinsine B due to...

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Hodgkinsine

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodkinsine was first reported by Ritchie et al (University of Sydney) in 1961. Hodgkinsine shows potent dose-​dependent...

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Heronapyrrole B

Heronapyrrole B is a member of a family of farnesylated 2-nitropyrroles isolated from a marine-derived Streptomyces found on the Australian Barrier Reef by Capon et al at the University of Queensland, Australia. Heronapyrrole B is potently active against...

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hemi-Oxanthromicin

hemi-Oxanthromicin is the monomer of (±)-oxanthromicin, first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. Unlike its co-metabolites, oxanthromicin and spiro-oxanthromicin, hemi-oxanthromicin does not inhibit...

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Helvolic Acid

Helvolic Acid is a triterpenoid antibacterial mycotoxin produced by Aspergillus and other fungal species, structurally related to cephalosporin P1 and fusidic acid. Helvolic acid is active against Gram positive and Gram negative organisms, including...

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