Antimicrobials

Indole-3-carboxylic acid

Indole-3-carboxylic acid is a tryptophan metabolite produced by microbiota in the human gut. Indole-3-carboxylic acid isolated from Streptomyces sp. is active against Gram positive bacteria, yeast and fungi. Indole-3-carboxylic acid induces resistance in...

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Indole-3-carboxaldehyde

Indole-3-carboxaldehyde is an endogenous metabolite of plants and is produced in humans by the metabolism of L-tryptophan in Lactobacillus and other gastrointestinal bacteria. Indole-3-carboxaldehyde is an immunomodulator, acting as an agonist of the...

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Hodgkinsine trimethyl triiodide

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. There is not much information on the biological activity of hodgkinsine trimethyliodide due to lack of availability of the...

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Hodgkinsine B

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodgkinsine B is the enantiomer of hodgkinsine. There is scant information on the biological activity of hodgkinsine B due to...

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Hodgkinsine

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodkinsine was first reported by Ritchie et al (University of Sydney) in 1961. Hodgkinsine shows potent dose-​dependent...

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Heronapyrrole B

Heronapyrrole B is a member of a family of farnesylated 2-nitropyrroles isolated from a marine-derived Streptomyces found on the Australian Barrier Reef by Capon et al at the University of Queensland, Australia. Heronapyrrole B is potently active against...

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hemi-Oxanthromicin

hemi-Oxanthromicin is the monomer of (±)-oxanthromicin, first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. Unlike its co-metabolites, oxanthromicin and spiro-oxanthromicin, hemi-oxanthromicin does not inhibit...

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Helvolic Acid

Helvolic Acid is a triterpenoid antibacterial mycotoxin produced by Aspergillus and other fungal species, structurally related to cephalosporin P1 and fusidic acid. Helvolic acid is active against Gram positive and Gram negative organisms, including...

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Griseofulvic Acid

Griseofulvic acid is a naturally occurring polyketide metabolite of the griseofulvin family. Griseofulvic acid, the demethylated metabolite of griseofulvin, is excreted in the urine of humans administered griseofulvin for the treatment of fungal...

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Fumitremorgin B

Fumitremorgin B is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Fumitremorgin B is active against a range of phytopathogenic fungi including Botrytis cinerea, Alternaria solani and alternata at 6.25 µg/mL. Fumitremorgen B has potent...

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Stephacidin B

Stephacidin B, the dimer of avrainillamide, is green pigment isolated from Aspergillus ochraceus and other Aspergillus sp.  Stephacidin B is more potent and selective than its monomeric analog, stephacidin A. Stephacidin B is rapidly converted to...

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Fervenulin

Fervenulin, structurally related to caffeine, was first isolated from Streptomyces fervens in 1959 and reported as a broad spectrum antibiotic, with antineoplastic properties. Fervenulin inhibits egg hatch and increases juvenile mortality of the...

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