Antitumor

Aphidicolin

Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has...

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Cytochalasin D

Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the...

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Venturicidin A

Venturicidin A (Aabomycin A1) is a 20-member macrolide glycoside compound that was first isolated from a Streptomyces sp. by Glaxo Labs in 1961. Venturicidin A is a potent antifungal and toxic antibiotic compound, that has also shown cytotoxicity...

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Nigericin

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Although Nigericin can be isolated as the free acid (under acidic conditions), like most...

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Narasin

Narasin (4-methylsalinomycin) is a carboxylic polyether antibiotic isolated from Streptomyces aureofaciens in 1978. Although Narasin is a derivative of Salinomycin, the metabolites are produced by different species and are not co-metabolites. Narasin is...

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TAN 420C

TAN 420C is a minor analogue of the herbimycin complex, isolated from Streptomyces hygroscopicus. TAN 420C is the hydroquinone of herbimycin C, and is known to exhibit antitumor activity. TAN 420C converts Rous sarcoma virus-infected rat kidney cells...

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Gliotoxin

Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species of Gliocladium, Aspergillus and Penicillium. Gliotoxin inhibits a number of thiol-requiring enzymes and displays antioxidant and immunomodulatory activity.Gliotoxin is soluble in...

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Lagosin

Lagosin is a pentaene antifungal produced by Streptomyces, first isolated in 1958 by researchers at MIT in the USA. The discovery was soon followed by several independent isolations as lagosin and cogomyin. Initially these metabolites were thought to be...

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Hygrolidin

Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumor cells, and inhibits the growth of solid tumor-derived...

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Enniatin B1

Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...

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Toxoflavin

Toxoflavin (PKF 118-310) is an azapteridine antibiotic produced by some species of Pseudomonas, Streptomyces, and Burkholderia gladioli that has antibiotic and anticancer properties.  It is also a yellow pigment that acts as a pH indicator changing...

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Asterric Acid

Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human...

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