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LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation...
Antimycin A1 is the most hydrophobic of the four analogs of the Antimycin A complex. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes.Antimycin...
Anhydroepiophiobolin A is a dehydrated analogue of ophiobolin epimerised at the C6 position. Anhydroepiophiobolin A is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many Bipolaris species. Prior to...
Tubercidin is a nucleoside metabolite first isolated from Streptomyces tubericidus. Tubercidin, like other nucleosides, is a broad spectrum potent chemotherapeutic agent active against viruses, bacteria, fungi, protozoans and tumors. Soluble in...
Tigecycline is a broad spectrum glycylcycline antibiotic with activity against multi-drug resistant organisms. It is a semisynthetic derivative of tetracycline, that is structurally similar to minocycline; however, it contains a large glycylamido...
Antimycin A2 is a homologue of the antimycin complex, first resolved from antimycin A1 in 1959. Antimycin A2, like all antimycins, is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A2 exhibits broad...
Antimycin A3 is an homolog of the Antimycin complex (syn: Antimycin A). Antimycin A3 is one of four closely related structures in the mixture (others include Antimycin A1, A2 and A4). First isolated in 1958 from Streptomyces blastimyceticus...
Bithionol is an aryl sulfide and anti-parasitic compound and has been found to have in vitro anti-cancer properties with ovarian cancer cell lines. It is an algaecide. Bithionol was formerly used in soaps and cosmetics until the U.S. FDA withdrew...
Antimycin A4 is the most polar of the major components of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A3. Antimycin A4 exhibits broad biological activity as an antifungal, anthelmintic,...
Enniatins are a family of depsipeptide ionophores, produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...
Antimycin (syn: Antimycin A) is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogs in the...
Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...
