(-)-Rugulosin is the optical isomer of the mycotoxin, (+)-Rugulosin, which was first isolated from Myrothecium verrucaria in 1968. The isomers appear not to be co-produced but both occur widely in several fungal genera. (-)-Rugulosin has been shown to have antiviral properties. (-)-Rugulosin is the less common and less studied isomer, and there are few comparative studies of the relative potency of the isomers.
(-)-Rugulosin is soluble in ethanol, methanol, DMF and DMSO.
|References||Breen J et al (1955) Rugulosin, a crystalline colouring matter of Penicillium rugulosum Thom. Biochem. J. 60: 618
Miller JD et al (2008) Effect of a Rugulosin-producing endophyte in Picea glauca on Choristoneura fumiferana. J. Chem. Ecol. 2008, 34, 362
Nakamura S et al (1971) Inhibition of phage growth by an antibiotic Rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect. Jpn. J. Microbiol. 5:113
Sankawa U et al (1968) Further studies on the structures of luteoskyrin, rubroskyrin and Rugulosin. Tet. Lett. 53:5557
Takeda N et al (1973) Fungal metabolites. XXXII. Renewed investigation on (-)-flavoskyrin and its analogs. T Tetrahedron 29:3703
Watts P et al (2003) Cytotoxicity against insect cells of entomopathogenic fungi of the genera Hypocrella (anamorph Aschersonia): Possible agents for biological control. Mycological Res. 107:581