Quinine is a naturally occurring alkaloid first isolated from the bark of the cinchona tree in 1820. It is a stereoisomer of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine. It functions as a potassium channel blocker and is used as an anti-malarial compound. Quinine can be used as an analytical reference standard during the chemical evaluation of alkaloids. Bark extracts have been used to treat malaria since 1632 (Sullivan, 2011) and Quinine was the first antimalarial compound used (Achan et al, 2011). Quinine is also used in food science and nutrition research as a bitterness standard.
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