• Trimethoprim packaged and labeled.

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SKU: T011

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Description

Trimethoprim is a bactericidal dihydrofolate reductase inhibitor.

TOKU-E offers two forms of trimethoprim: trimethoprim (T011) and trimethoprim lactate (T012). Trimethoprim has low solubility in aqueous solution (0.4 mg/mL). Trimethoprim lactate is freely soluble in aqueous solution (19.6 mg/mL).

    CAS Number

    738-70-5

    Molecular Formula

    C14H18N4O3

    Molecular Weight

    290.32

    Mechanism of Action

    Trimethoprim prevents bacteria from taking up folic acid which is used to synthesize the essential DNA nucleotide thymine.

    Storage Conditions

    2-8 °C

    Tariff Code

    2933.59.2200

    Spectrum

    Trimethoprim is a broad spectrum antibiotic used extensively against bacteria responsible for urinary tract infections.

Applications

    Microbiology Applications

    Trimethoprim is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 0.25 µg/mL - 64 µg/mL
    • Haemophilus influenzae 0.15 µg/mL - 16 µg/mL
    • For a complete list of trimethoprim MIC values, click here.

    Media Supplement

    Trimethoprim can be used as a selective agent in several types of isolation media:

    Columbia Blood Agar - Campylobacter selective supplement (Skirrow)

    Columbia Blood Agar - Campylobacter selective supplement (Blaser-Wang)

    Campylobacter Agar - Campylobacter Selective Supplement (Preston)

    Columbia Blood Agar - Helicobacter pylori Selective Supplement (Dent)

    Bolton Broth - Bolton Broth Selective Supplement

    Campylobacter Agar Base - Modified Preston Campylobacter Selective Supplement

    Bolton Broth - Modified Bolton Broth Selective Supplement

    ChromogenicBacillus cereus Agar - Chromogenic Bacillus cereus Selective Supplement

Specifications

    Form

    Powder

    Appearance

    White or yellowish-white powder

    Melting Point

    199°C-203°C

    Assay

    (On Dried Basis): 98.5-101.0%

    Loss on Drying

    ≤0.5%

    Residue On Ignition

    ≤0.1%

References

    References

    Weir, D. G., and J. Scott. "Mechanism of the Antimicrobial Drug Trimethoprim Revisited."PubMed (2000): 2519-524. www.ncbi.gov. 14 Dec. 2000. Web. 21 Aug. 2012.

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