• Ticarcillin disodium, USP packaged and labeled.

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SKU: T034

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Description

Ticarcillin disodium is an extended spectrum β-lactam in the carboxypenicillin family.

TOKU-E offers two forms of ticarcillin disodium: ticarcillin disodium (T027) and ticarcillin disodium w/clavulanate potassium (T020). Both forms are freely soluble in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Ticarcillin disodium can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.

    CAS Number

    4697-14-7

    Molecular Formula

    C15H14N2Na2O6S2

    Molecular Weight

    428.39 g/mol

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.10.5000

    Spectrum

    Ticarcillin disodium is a broad spectrum antibiotic targeting a wide range of Gram positive and gram negative organisms.

Applications

    Microbiology Applications

    Ticarcillin disodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus influenzae 0.2 µg/mL – 0.8 µg/mL
    • Streptococcus pneumoniae 0.1 µg/mL – 1.6 µg/mL
    • For a complete list of ticarcillin disodium MIC values, click here.

    Media Supplements

    Ticarcillin can be used as a selective agent in several types of isolation media:

    Burkholderia cepacia Agar Base - Burkholderia cepacia Selective Supplement

Specifications

    Form

    Powder

    Appearance

    Creamy-white hygroscopic non-crystalline powder

    Source

    Semi-synthetic

    Impurity Profile

    Impurity A| (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[(thiophen-3-yl)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (decarboxyticarcillin)||C14H15N2O4S2|339.41| Impurity B| (thiophen-3-yl)acetic acid|6964-21-2|C6H6O2S|142.18| Impurity C| 2-(thiophen-3-yl)propanedioic acid (3-thienylmalonic acid|21080-92-2|C7H6O4S|186.19| Impurity D| (4S)-2-[carboxy[[2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethylthiazolidine-4-carboxylic acid (penicilloic acids of ticarcillin)||C15H17N2O7S2|401.44| Impurity E| (4S)-2-[[[2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethylthiazolidine-4-carboxylic acid (penilloic acids of ticarcillin)||C14H17N2O5S2|357.43|

    Water Content (Karl Fisher)

    <6.0%

    pH

    6.0-8.0

    Melting Point

    252.6 °C

    Optical Rotation

    +172° to +187°

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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