• Streptomycin sulfate packaged and labeled.

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SKU: S008

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Description

Streptomycin sulfate is a freely soluble aminoglycoside antibiotic.

    CAS Number

    3810-74-0

    Molecular Formula

    C21H39N7O12 · 1.5H 2SO4

    Molecular Weight

    728.69

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.20.0000

    Spectrum

    Streptomycin sulfate targets primarily Gram positive bacteria and Mycobacterium. Interestingly, streptomycin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."

Applications

    Microbiology Applications

    Streptomycin sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and Mycobacterium microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Mycobacterium tuberculosis 1 µg/mL – 2 µg/mL
    • Escherichia coli 0.5 µg/mL – 7.8 µg/mL
    • For a complete list of streptomycin MIC values, click here.

    Media Supplements

    Streptomycin can be used as a selective agent in several types of isolation media:

    STAA Agar - STAA Selective Supplement

    STAA Agar - STA Selective Supplement

    Plant Biology Applications

    Streptomycin has been used in a number of crop protection applications in the USA to prevent fire blight, soft rot caused by Pectobacterium species, bacterial blight caused by Pseudomonas cichorii, fruit-spotting in apples and pears, and bacterial spot in peppers and tomatoes caused by Xanthomonas spp. (McManus et al. 2002).

Specifications

    Form

    Powder

    Appearance

    A white or almost white powder

    Source

    Streptomyces Griseus

    pH

    4.5-7.0

    Melting Point

    157-162°C

    Assay

    (On Dried Basis): 650-850 µg/mg

    Loss on Drying

    ≤5.0%

References

    References

    Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

    McManus P.S., Stockwell V.O., Sundin G.W. and Jones A.L., 2002, Antibiotic use in plant agriculture. Annu. Rev. Phytopathol. 2002. 40:443–65

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