• Pyrazinamide packaged and labeled.

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SKU: P020

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Description

Pyrazinamide is a sparingly soluble bactericidal antitubercular drug.

    CAS Number

    98-96-4

    Molecular Formula

    C5H5N3O

    Molecular Weight

    123.11

    Mechanism of Action

    The mechanism of pyrazinamide is not entirely understood. It is speculated that pyrazinamide enters a target cell and is converted into pyrazinoic acid (POA) which disrupts normal membrane permeability functions. Internal pH of the cell begins to decrease as POA accumulates in the cell’s cytoplasm which is thought to inhibit fatty acid synthase activity.

    Storage Conditions

    2-8°C

    Tariff Code

    2933.99.4200

    Spectrum

    Pyrazinamide is used almost exclusively against Mycobacterium tuberculosis.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤0.5%

    Melting Point

    189-191°C

    Assay

    99.0-100.5

References

    References

    Cynamon, M. H., and Et Al. "Activity of N-propyl Pyrazinoate against Pyrazinamide-resistant Mycobacterium Tuberculosis: Investigations into Mechanism of Action of and Mechanism of Resistance to Pyrazinamide." Antimicrobial Agents and Chemotherapy 39.6 (1995): 1269-271. www.ncbi.gov. American Society for Microbiology. Web. 28 Aug. 2012.

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