Pyrazinamide is a sparingly soluble bactericidal antitubercular drug.
CAS Number
98-96-4
Molecular Formula
C5H5N3O
Molecular Weight
123.11
Mechanism of Action
The mechanism of pyrazinamide is not entirely understood. It is speculated that pyrazinamide enters a target cell and is converted into pyrazinoic acid (POA) which disrupts normal membrane permeability functions. Internal pH of the cell begins to decrease as POA accumulates in the cell’s cytoplasm which is thought to inhibit fatty acid synthase activity.
Storage Conditions
2-8°C
Tariff Code
2933.99.4200
Spectrum
Pyrazinamide is used almost exclusively against Mycobacterium tuberculosis.