Pyrazinamide

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Pyrazinamide

SKU: P020

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Description

Pyrazinamide is a sparingly soluble bactericidal antitubercular drug.

CAS Number

98-96-4

Molecular Formula

C₅H₅N₃O

Molecular Weight

123.11

Mechanism of Action

The mechanism of pyrazinamide is not entirely understood. It is speculated that pyrazinamide enters a target cell and is converted into pyrazinoic acid (POA) which disrupts normal membrane permeability functions. Internal pH of the cell begins to decrease as POA accumulates in the cell’s cytoplasm which is thought to inhibit fatty acid synthase activity.

Storage Conditions

2-8°C

Tariff Code

2933.99.4200

Spectrum

Pyrazinamide is used almost exclusively against Mycobacterium tuberculosis.

Applications

Specifications

Form

Powder

Appearance

White crystalline powder

Source

Synthetic

Water Content (Karl Fischer)

≤0.5%

Melting Point

189-191°C

Assay

99.0-100.5

Technical Data

References

Cynamon, M. H., and Et Al. "Activity of N-propyl Pyrazinoate against Pyrazinamide-resistant Mycobacterium Tuberculosis: Investigations into Mechanism of Action of and Mechanism of Resistance to Pyrazinamide." Antimicrobial Agents and Chemotherapy 39.6 (1995): 1269-271. www.ncbi.gov. American Society for Microbiology. Web. 28 Aug. 2012.