• Nicotinamide (Vitamin B3), USP packaged and labeled.

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SKU: N018

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Description

Nicotinamide (Vitamin B3), USP is water-soluble amide form of Nicotinic acid (Vitamin B3).   It is a poly (ADP-ribose) polymerase (PARP) inhibitor, involved in regulation of many cellular processes.  It  shows promise in cell therapy research for diabetes, since it can induce embryonic stem cells into insulin-secreting cells. 

Nicotinamide (Vitamin B3), USP conforms to United States Pharmacopoeia specifications.

    CAS Number

    98-92-0

    Molecular Formula

    C6H6N2O

    Molecular Weight

    122.12 g/mol

    Mechanism of Action

    In cells, nicotinamide is the precursor to nicotinamide adenine dinucleotide(NAD), an essential coenzyme in ATP production and substrate for poly-ADP-ribose polymerase-1 (PARP-1). It is also a precursor to nicotinamide adenine dinucleotide phosphate ( NADP), both of which are involved in redox reactions. PARP inhibitors are involved in many cellular processes such as DNA repair, cell cycle progression, and cell death.

    Storage Conditions

    <30°C

    Tariff Code

    2936.24.0000

Applications

    Cancer Applications

    Nicotinamide has also been used as an anti-cancer agent to inhibit PARP-1, an enzyme responsible for repairing DNA damage caused by chemotherapy treatment.

    Eukaryotic Cell Culture Applications

    In studies with embryonic stem cells, researchers found that undifferentiated mouse embryonic stem cells treated with Nicotinamide showed an 80% decrease in cell proliferation and induced differentiation into insulin-secreting cells. Nicotinamide can increase insulin content of cells differentiated form embryonic stem cells. This has implications in cell therapy for treatment of diabetes based on embryonic stem cells (Vaca et al, 2008).

Specifications

    Form

    Powder

    Appearance

    White crystalline

    Melting Point

    128-131 °C

References

    References

    Surjana D, Halliday GM and Damian DL (1010)  Role of Nicotinmide in DNA damage, mutagenesis, and DNA repair. J. Nucl. Acids. ID 157591 doi 10.4061 13 pp.

    Tentori L and Graziani G (2005)  Chemopotentation by PARP inhibitors in cancer therapy. Pharmacol. Res. 52(1):25-33

    Vaca P et al (2008)  Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells. Exp. Cell Res. 314(5):969-974

    Ungerstedt, JS et al (2003)  Nicotinamide Is a potent inhibitor of proinflammatory cytokines. Clin. Exper. Immunol. 131(1):48-52

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