• Minocycline hydrochloride packaged and labeled.

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SKU: M008

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Description

Minocycline HCl is a freely soluble (50 mg/mL) broad spectrum tetracycline antibiotic.

    CAS Number

    13614-98-7

    Molecular Formula

    C23H27N3O7 ·HCl

    Molecular Weight

    493.94

    Mechanism of Action

    Tetracyclines inhibit bacterial protein synthesis by entering the cell and binding to the 30s ribosomal subunit preventing binding of tRNA.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.30.0000

    Spectrum

    Minocycline HCl is a broad spectrum antibiotic commonly used against bacteria which cause upper respiratory tract infections.

Applications

    Microbiology Applications

    Minocycline HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Neisseria meningitidis 0.06 µg/mL - 0.12 µg/mL
    • Streptococcus pneumoniae 0.03 µg/mL - 8 µg/mL
    • For a complete list of minocycline MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Yellow crystalline powder

    Source

    Synthetic

    Water Content (Karl Fischer)

    4.3-8.0%

    pH

    3.5-4.5

    Assay

    (On Dried Basis): 890 - 950 µg/mg

References

    References

    Chopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance." Microbiology and Molecular Biology Reviews (2001): 232-60. Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012.

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