SKU: M003  / 
    CAS Number: 3963-95-9

    Methacycline hydrochloride

    $100.25 - $144.82
    Methacycline HCl is a member of the tetracycline antibiotics and is more active against Gram-negative and Gram-positive bacteria than tetracycline and demethylchlortetracycline.
    ApplicationMethacycline HCl can be used as a synthetic precursor of doxycycline hyclate.
    Mechanism of ActionMethacycline inhibits protein synthesis by preventing amino-acyl tRNA from binding to the “A” site in the bacterial ribosome.
    SpectrumMetacycline has a broad spectrum of activity and is effective against several clinically significant pathogenic bacteria.
    Impurity ProfileOxytetracyline: Not more than 1.0%
    Doxycycline: Not more than 2.0%
    Other impurities: Not more than 0.5%
    Total impurities: Not more than 3.0%
    Molecular FormulaC22H22N2O• HCl
    ReferencesHubert, E. G., G. M. Kalmanson, J. Z. Montgomerie, and L. B. Guze. "Activity of Methacycline, Related Tetracyclines, and Other Antibiotics Against Various L-Forms and Their Parent Bacteria In Vitro." Antimicrobial Agents and Chemotherapy 2.4 (1972): 276-80.

    hopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance."Microbiology and Molecular Biology Reviews (2001): 232-60.Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012.