• Mezlocillin sodium packaged and labeled.

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SKU: M017

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Description

Mezlocillin sodium is an extended spectrum β-lactam antibiotic and is sparingly soluble in aqueous solution 0.47 mg/mL.

    CAS Number

    59798-30-0

    Molecular Formula

    C21H24N5NaO8S2

    Molecular Weight

    561.57

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases, however, mezlocillin is resistant to a number of β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.10.5000

    Spectrum

    Mezlocillin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Mezlocillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Helicobacter pylori 0.125 µg/mL – 0.25 µg/mL
    • For a complete list of mezlocillin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White to off-white crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤6.0%

    pH

    4.5-8.0

    Optical Rotation

    +175° to +195°

    Assay

    (On Dried Basis): 838-978 µg/mg

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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