• Mezlocillin sodium packaged and labeled.

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SKU: M017

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Description

Mezlocillin sodium is broad-spectrum, semisynthetic, β-lactam antibiotic and ureido penicillin derived from ampicillin.  It is sparingly soluble in aqueous solution. 

    CAS Number

    59798-30-0

    Molecular Formula

    C21H24N5NaO8S2

    Molecular Weight

    561.57

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases, however, mezlocillin is resistant to a number of β-lactamases.

    Storage Conditions

    2-8 °C

    Tariff Code

    2941.10.5000

    Spectrum

    Mezlocillin is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria.

Applications

    Eukaryotic Cell Culture Applications

    Mezlocillin did not cause any cytotoxicity in cell cultures of mouse sarcoma L-1, human lung cancer E-14, or human malignant melanoma MEW (Roszkowski et al, 1984).

    Microbiology Applications

    Mezlocillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:

    • Helicobacter pylori 0.125 µg/mL – 0.25 µg/mL
    • For a complete list of Mezlocillin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    white to off-white crystalline powder

    Source

    semi-synthetic

    Water Content (Karl Fischer)

    ≤6.0%

    pH

    4.5-8.0

    Optical Rotation

    +175° to +195°

    Assay

    (On Dried Basis): 838-978 µg/mg

References

    References

    Bodey GP and Pan T (1977) Mezlocillin: In vitro studies of a new broad-spectrum penicillin.  Antimicrob.Agents Chemother. 11 (1): 74-79  PMID 836016

    Fu KP and Neu HC (1978)  Azlocillin and Mezlocillin: New ureido penicillins. Antimicrob. Agents Chemother. 13(6):930-938  PMID 677860

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103:51

    Roszkowski K, Ko HL, Roszkowski W, Jeljaszewicz J, and Pulverer G. (1984)  Effects of cefotaxime, clindamycin, mezlocillin, and piperacillin on mouse sarcoma L-1 tumor. Cancer Immunol. 18(3):164-168  PMID 6095992

    Soares LA and Trabulsi LR (1979)  Studies on the antibacterial activity of two new acylureidopenicillins, mezlocillin and azlocillin. Arzneimittelforschung. 29(12a):1932-1934.  PMID 543893

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