• Imipenem packaged and labeled.

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SKU: I001

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Description

Imipenem is a β-lactam antibiotic in the carbapenem subgroup and is soluble in aqueous solution at >5 mg/mL. Imipenem has been found to be effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line beta-lactam antibiotics and certain cephalosporins.

TOKU-E offers two forms of imipenem: imipenem (I001) and imipenem w/ cilastatin (I002). Cilastatin is a chemical which inhibits the human enzyme dehydropeptidase which degrades imipenem.

    CAS Number

    74431-23-5

    Molecular Formula

    C12H17N3O4S · H2O

    Molecular Weight

    317.36 g/mol

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many members of the carbapenem subgroup, imipenem is highly resistant to β-lactamase activity.

    Storage Conditions

    -20 °C

    Tariff Code

    2941.90.5000

    Spectrum

    Imipenem is a broad spectrum antibiotic targeting a wide range of aerobic and anaerobic gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Imipenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Imipenem has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.25 µg/mL – 12 µg/mL
    • Bacteroides fragilis 0.008 µg/mL – 1 µg/mL
    • For a complete list of imipenem MIC values, click here.

    Plant Biology Applications

    Imipenem has been shown to be effective against bacteria from the genus Burkholderia, a well described pathogen in onions, bulbs, and mushrooms. A study by Sojanova et. al. (2007) reviewed the activity of imipenem against the causal agents of sour skin, slippery skin, cavity disease, and others in onion, bulbs, and mushrooms respectively. Imipenem has been shown to be effective against Burkholderia gladioli in some in vitro applications. Although not well characterized in plant culture, imipenem may be an effective treatment for plant diseases caused by Burkholderia species.

Specifications

    Form

    Powder

    Appearance

    White to light yellow crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    5.0% - 8.0%

    Optical Rotation

    +84° - +89°

    Assay

    (On Dried Basis): Not less than 95.0%

    Residue On Ignition

    Not more than 0.2%

    Heavy Metals

    Not more than 0.002%

References

    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

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