• Imipenem packaged and labeled.

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SKU: I001

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Imipenem is a broad-spectrum β-lactam antibiotic, a carbapenem effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae, a group of pathogenic microbes resistant to many first line β-lactam antibiotics and certain cephalosporins.  It is soluble in aqueous solution.

We also offer:

  • Imipenem mixture w/ cilastatin (I005).

    CAS Number


    Molecular Formula

    C12H17N3O4S · H2O

    Molecular Weight

    317.36 g/mol

    Mechanism of Action

    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many members of the carbapenem subgroup, imipenem is highly resistant to β-lactamase activity.

    Storage Conditions

    -20 °C

    Tariff Code



    Imipenem is a broad-spectrum.  targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria.


    Microbiology Applications

    Imipenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Imipenem has also shown high potency against high-resistant superbug strains.Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:

    • Pseudomonas aeruginosa 0.25 µg/mL – 12 µg/mL
    • Bacteroides fragilis 0.008 µg/mL – 1 µg/mL
    • For a representative list of Imipenem MIC values, click here.

    Plant Biology Applications

    Imipenem has been shown to be effective against bacteria from the genus Burkholderia, a well described plant pathogen, and was shown to be effective for sour skin (onions), slippery skin (bulbs), and cavity disease (mushrooms)(Sojanova et al, 2007).





    White to light yellow crystalline powder



    Water Content (Karl Fischer)

    5.0% - 8.0%

    Optical Rotation

    +84° - +89°


    (On Dried Basis): Not less than 95.0%

    Residue On Ignition

    Not more than 0.2%

    Heavy Metals

    Not more than 0.002%



    Berg PH, Voit EO and White RL (1996)  A pharmacodynamic model for the action of the antibiotic imipenem on Pseudomonas aeruginosa populations in vitro. Bltn. Mathcal. Biol. 58(5):923-938 

    Guzmán F (2008)  Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action. Medical Pharmacol. Pharmacology Corner, 29 Nov. 2008

    Pitout JD, Sanders CC, Sanders WE (1997)  Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 103:51

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