• Fosfomycin sodium packaged and labeled.

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SKU: F013

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Description

Fosfomycin sodium is an antibiotic which inhibits cell wall synthesis and is freely soluble in aqueous solution at 50 mg/mL.

    CAS Number

    26016-99-9

    Molecular Formula

    C3H5Na2O4P

    Molecular Weight

    182.02

    Mechanism of Action

    Fosfomycin prevents peptidoglycan synthesis by inhibiting MurA, an enzyme responsible for synthesizing N-acetylmuramic acid or NAM, a major component of peptidoglycan.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.5000

    Spectrum

    Fosfomycin sodium is a broad spectrum antibiotic frequently used to treat bacterial infections of the urinary tract. Fosfomycin has been found to be effective against certain β-lactam resistant strains of VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."

Applications

    Microbiology Applications

    Fosfomycin sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Escherichia coli 0.19 µg/mL – 64 µg/mL
    • Helicobacter pylori 0.05 µg/mL – 12.5 µg/mL
    • For a complete list of fosfomycin sodium MIC values, click here.

    Media Supplements

    Fostfomycin can be used as a selective agent in several types of isolation media:

    Listeria Selective Agar - Listeria Selective Supplement

    Listeria Selective Agar - Modified Listeria Selective Supplement

Specifications

    Form

    Powder

    Appearance

    White or off-white powder

    Source

    Streptomyces Spp.

    Impurity Profile

    Impurity A| disodium (1,2-dihydroxypropyl)phosphonate||||

    Water Content (Karl Fisher)

    ≤1.0%

    pH

    9.0-10.5

    Melting Point

    >300°C

    Optical Rotation

    -13° to -15°

    Assay

    (On Dried Basis): 95.0-101.0%

References

    References

    Falagas, Matthew E., and Antonia C. Kastaris. "Fosfomycin for the Treatment of Multidrug-resistant, including Extended-spectrum β-lactamase Producing, Enterobacteriaceae Infections: A Systematic Review." The Lancet: Infectious Diseases 10 (2010): 43-50. Antimicrobe.org. Web. 21 Aug. 2012.

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