• Florfenicol packaged and labeled.

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SKU: F002

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Description

Florfenicol is a bacteriostatic antibiotic similar to chloramphenicol which inhibits bacterial protein synthesis.  Florfenicol is soluble in water and lipid solvents.

    CAS Number

    73231-34-2

    Molecular Formula

    C12H14Cl2FNO4S

    Molecular Weight

    358.21

    Mechanism of Action

    After entering a bacterial cell, florfenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to florphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.40.0000

    Spectrum

    Florfenicol is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria, especially those which cause bovine respiratory infections.

Applications

    Microbiology Applications

    Florfenicol is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Haemophilus parasuis 0.24 µg/mL – 4 µg/mL
    • Escherichia coli 0.5 µg/mL – 128 µg/mL
    • For a complete list of florfenicol MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White crystalline powder

    Source

    Derivative of Thiamphenicol

    pH

    4.5-6.5

    Melting Point

    152-156°C

    Optical Rotation

    -16° to -19°

    Assay

    (On Dried Basis): ≥98.0%

    Loss on Drying

    ≤0.5%

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