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SKU: D001

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Description

Daunorubicin HCl is a water soluble anthracycline chemotherapeutic agent produced by Streptomyces coeruleorubidus.

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    CAS Number

    23541-50-6

    Molecular Formula

    C27H29NO10 · HCl

    Molecular Weight

    563.98

    Mechanism of Action

    Daunorubicin acts as a polymerase inhibitor and demonstrates DNA intercalation activity which effectively inhibits cancer progress.

    Storage Conditions

    2-8°C.

    Tariff Code

    2941.90.3000

Applications

    Cancer Applications

    Daunorubicin HCl has shown to be useful for treatment of acute myeloid leukemia.

Specifications

    Form

    Powder

    Appearance

    Orange-red crystalline powder

    Source

    Streptomyces peucetius

    Water Content (Karl Fischer)

    ≤3.0%

    pH

    4.5-6.5

    Assay

    (On Dried Basis): 84.2-103.0%

    Heavy Metals

    ≤0.001%

References

    References

    Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res. 35, 1542-1546, (1975) Abstract

    Tan C, Tasaka H, Yu KP, Murphy ML, Karnofsky DA (March 1967). "Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia". Cancer 20 (3): 333–53

    Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells". Mol Pharmacol 45 (4): 649–56

     

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