• Colchicine packaged and labeled.

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SKU: C093

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Description

Colchicine is a mitotic poison which has been used in research as a chemotherapeutic agent for cancer.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    CAS Number

    64-86-8

    Molecular Formula

    C22H25NO6

    Molecular Weight

    399.44

    Mechanism of Action

    Since one of the defining characteristics of cancer cells is a significantly increased rate of mitosis, cancer cells are significantly more vulnerable to colchicine poisoning than are normal cells. However, the therapeutic value of colchicine against cancer is (as is typical with chemotherapy agents) limited by its toxicity against normal cells.

    Storage Conditions

    2-8 °C

    Tariff Code

    2936.99.0000

Applications

    Cancer Applications

    Cochicine can be used to study the effects of mitosis in cancer cells.

    Eukaryotic Cell Culture Applications

    Colchicine is routinely used to select for cells containing resistance in the MDCK (NBL-2) cell line at an effective concentration of 800 µg/mL. For additional information on your cell culture needs, please visit our cell-culture database.

Specifications

    Form

    Powder

    Appearance

    Light Yellow Powder

    Water Content (Karl Fischer)

    ≤5.0%

    Assay

    (HPLC): ≥98.0%

    Sulfated Ash

    ≤2.0%

    Heavy Metals

    ≤10 ppm

References

    References

     Fakih, M., Replogle, T., Lehr, J. E., Pienta, K. J. and Yagoda, A. (1995), Inhibition of prostate cancer growth by estramustine and colchicine. Prostate, 26: 310–315. doi: 10.1002/pros.2990260606

    Jordan, A., et al., Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med. Res. Rev. 18, 259-296, (1998)

    DeVincenzo, R., et al., Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. Anticancer Drug Des. 13, 19-33, (1998)

    Karapidaki, I., et al., Genotoxic, Cytostatic, Antineoplastic And Apoptotic Effects Of Newly Synthesized Antitumour Steroidal Esters. Mol. Cell. 675, 51-9, (2009)

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