Colchicine is a classic mitotic inhibitor, disrupting cell division by preventing assembly of microtubules in the mitotic spindle via inhibition of tubulin polymerization. It has pleiotropic effects; It is an anti-inflammatory agent and has been used for Gout suppression, and other inflammatory conditions such as familial Mediterranean fever. It can also induce apoptosis in a variety of cells and is used in cancer research as a chemotherapeutic agent. It is also used in cytogenetics to study chromosomes. Colchicine has been studied in COVID-19 research.
Colchicine was approved by the FDA in 2009, but its use dates back two centuries. Papyri dated 1500 BC describe the Colchicine’s source plant- Colchicum automnale (autumn crocus) for pain and inflammation, making it one of the world’s oldest anti-inflammatory agents.
There is a large body of data demonstrating Colchicine’s inhibitory effects on neutrophil activity, cytokine generation, and the inflammation/thrombosis interface. It was found to have utility against SARS-CoV2 in the ColCorona clinical trial, a phase 3, randomized, double-blind, placebo-controlled multicenter clinical trial of over 4500 participants in Canada.
Colchicine is sparingly soluble in DMSO and DMF. It is slightly soluble in water and ethanol.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for questions.