• Cephalexin hydrate packaged and labeled.

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SKU: C024

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Description

Cephalexin hydrate is a first generation cephalosporin antibiotic and is slightly soluble in aqueous solution (1.789 mg/mL).

    CAS Number

    23325-78-2

    Molecular Formula

    C16H17N3O4S · H2O

    Molecular Weight

    347.39 g/mol (anhydrous basis)
    365.41 g/mol (monohydrate)

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C. Protected from light.

    Tariff Code

    2941.90.3000

    Spectrum

    Cephalexin hydrate is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria especially those which cause respiratory infections.

Applications

    Microbiology Applications

    Cephalexin hydrate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Streptococcus pyogenes 0.2 µg/mL – 12.5 µg/mL
    • Streptococcus pneumoniae 0.78 µg/mL – 3.12 µg/mL
    • For a complete list of cephalexin MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or almost white crystalline powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    4.0-8.0%

    pH

    3.0-5.5

    Optical Rotation

    +149° to +158°

    Assay

    950-1030 µg/mg

Technical Data

Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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