• Ceftizoxime sodium packaged and labeled.

click on thumbnail to zoom
SKU: C021

Size  
Quantity:
  Click 'Bulk Order' for 10 or more
Price: make selection(s)
Description

Ceftizoxime sodium is a third generation cephalosporin antibiotic and is considered very soluble in aqueous solution.

    CAS Number

    68401-82-1

    Molecular Formula

    C13H12N5NaO5S2

    Molecular Weight

    405.38

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases; however, ceftizoxime is stable in the presence of these inactivating enzymes.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Ceftizoxime is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Applications

    Microbiology Applications

    Ceftizoxime sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Haemophilus spp. 0.008 µg/mL – 0.25 µg/mL
    • Neisseria spp. 0.004 µg/mL – 0.015 µg/mL
    • For a complete list of ceftizoxime MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or pale yellow crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤8.5%

    pH

    6.0-8.0

    Optical Rotation

    +125° to +145°

    Assay

    (On Dried Basis): 850-995 µg/mg

    Impurities

    Individual Impurity: ≤0.5%
    Total Impurities: ≤1.0%
    Ceftizoxime Polymer: ≤0.1%

Technical Data

Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

Other Items In This Category