SKU: C014

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Description

Cefpirome sulfate is a fourth generation cephalosporin antibiotic.

TOKU-E offers two forms of cefpirome: cefpirome sulfate (C014) and cefpirome sulfate w/ sodium carbonate (C055). Cefpirome sulfate w/ sodium carbonate is a mixture of cefpirome sulfate and anhydrous sodium carbonate and is commonly used to stabilize pH.

    CAS Number

    98753-19-6

    Molecular Formula

    C22H22N6O5S2H2SO4

    Molecular Weight

    612.66

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefpirome is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria. Many Bacteroides, Enterococci, and Haemophilus species have developed resistance to cefpirome.

Applications

    Microbiology Applications

    Cefpirome sulfate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Campylobacter jejuni 0.5µg/mL – 8 µg/mL
    • Klebsiella pneumoniae 0.032 µg/mL – 0.125 µg/mL
    • For a complete list of cefpirome MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    White or almost white crystalline powder

    Source

    Synthetic

    Water Content (Karl Fisher)

    ≤4.0%

    pH

    (2% in H2O): 1.3-2.5

    Assay

    ≥99.0% (on dried basis)

    Residue On Ignition

    ≤0.1%

    Heavy Metals

    ≤20ppm

    Impurities

    Single Impurity: ≤0.2%
    Total Impurities: ≤1.0%

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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