• Cefozopran hydrochloride packaged and labeled.

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SKU: C099

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Description

Cefozopran HCl is a fourth generation cephalosporin antibiotic and is freely soluble in DMSO and slightly soluble in water.

    CAS Number

    113981-44-5

    Molecular Formula

    C19H17N9O5S2•HCl

    Molecular Weight

    551.99

    Mechanism of Action

    Similar to β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefozopran is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria including Pseudomonas aeruginosa.

Applications

    Microbiology Applications

    Cefozopran has been shown to be useful against the multi drug resistant MRSA when used in combination with other antibiotics including vancomycin and teicoplanin.

Specifications

    Form

    Powder

References

    References

    Hayashi, R., and A. Lmada. "Therapeutic Effect of Cefozopran (SCE-2787), a New Parenteral Cephalosporin, against Experimental Infections in Mice." Antimicrobial Agents and Chemotherapy 37.1 (1993): 100-05. www.ncbi.gov. Web. 27 Aug. 2012.

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    Toyokawa, M., and Et Al. "In Vitro Combined Effects of Cefozopran/teicoplanin and Cefozopran/vancomycin on Methicillin-resistant Staphylococcus Aureus." Journal of Chemotherapy 15.1 (2003): 31-36. Ncbi.gov. Web. 18 Sept. 2012.

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