• Cefepime packaged and labeled.

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SKU: C008

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Cefepime is a broad-spectrum, fourth-generation cephalosporin antibiotic.  It is commonly used in antimicrobial susceptibility testing.  It is sparingly soluble in water (17.3 mg/ml).  Cefepime has potential for use as an antitumor agent, showing inhibition of human breast cancer cells in vitro when complexed with manganese.

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  • Cefepime Hydrochloride (C009)

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    Mechanism of Action

    Like β-lactams, cephalosporins interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases. Interestingly, cefepime is resistant to various β-lactamases encoded by otherwise resistant β-lactam bacteria strains.

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    Cefepime is a broad-spectrum antibiotic targeting a wide variety of naturally antibiotic resistant Gram-positive and Gram-negative bacteria. Some of these naturally resistant bacteria include Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.


    Cancer Applications

    Cefepime (50mM) was mixed with 8 different metal salts (copper, zinc, cobalt, nickel, cadmium, chromium, iron, and manganese ) in a 1:1 ratio and evaluated for proteasome-inhibitory and anti-proliferative properties using MDA-MB 231 human breast cancer cells. The complex with manganese had the highest inhibition of cell proliferation and proteasome activity. The complex induced apoptosis in a dose-and time-dependent manner and has the potential for use as an antitumor agent (Zhang et al, 2015).

    Microbiology Applications

    Cefepime is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram -positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

    • Pseudomonas aeruginosa 32 µg/mL – 256 µg/mL
    • Staphylococcus aureus 2 µg/mL – 16 µg/mL.
    • For a representative complete list of cefepime MIC values, click here.

    Cefepime was used in a MALDI-TOF MS-based direct-on-target microdroplet growth assay as part of a screening panel for rapid detection of ESBL, and AmpC β-Lactamases in Enterobacterales  (Correa-Martinez et al, 2019). 





    White or off-white powder





    Georgopapadakou NH and Bertasso A (1993)  Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli.  Antimicrob. Agents. Chemother. 37(3):559-565

    Zhang Z, Bi C, Fan Y, Wang H and Bao Y (2015) Cefepime, a fourth-generation cephalosporin, in complex with manganese, inhibits proteasome activity and induces the apoptosis of human breast cancer cells. Int. J. Molec. Med. 36(4): 1143-1150

    Cefepime from TOKU-E:

    Correa-Martinez C, Idelevich EA, Sparbier K, Kostrzewa M, and Becker K (2019)  Rapid detection of extended-spectrum B-lactamases (ESBL) and AmpC B-Lactamases in Enterobacterales: Development of a screening panel using the MALDI-TOF MS-based direct-on-target microdroplet growth assay. Front. Microbiol. 10:13  PMID 30733710

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