Paclitaxel is a unique anti-tumor agent derived from the bark of the Pacific Yew tree. Pacitaxel is sparingly soluble in ethanol, DMSO, and DMF.
|Mechanism of Action||Paclitaxel prevents tumor growth by stabilizing microtubules during mitosis in the G2/M growth phase leading to cell death.|
|Cancer Applications||Paclitaxel can be used to study effects on actively dividing tumor cells.|
Fiser, Andras, et al. "Insights into the Mechanism of Microtubule Stabilization by Taxol." PNAS 103.27 (2006): 10166-0173. Pnas.org. Web. 21 June 2013.
Horwitz, S. B. "Taxol (paclitaxel): Mechanisms of Action." Annals of Oncology 6th ser. 6 (1994): n. pag. Ncbi.gov. Web. 21 June 2013