SKU: N026  / 
    CAS Number: 3947-65-7

    Neomycin A Sulfate (Neamine), EvoPure®


    Neomycin A Sulfate (Neamine), EvoPure®  is a highly purified Neomycin compound. Neomycin A has been found to have the lowest antibacterial activity (~ 10% of the activity of Neomycin B).  Neomycin A can inhibit angiogenin translocation in tumor cell nuclei effectively inhibiting tumor growth. Neomycin A has a lower toxicity profile than other Neomycin components making it a favorable tool in cancer research. 

    We also offer:

    • Neomycin Sulfate, USP (N003)
    • Neomycin Sulfate, EP (N012)
    • Neomycin B Sulfate, EvoPure® (N019)
    • Neomycin C Sulfate, EvoPure® (N022)
    • Neomycin solution (10 mg/ml Neomycin in 0.9% NaCl)(N027)

    Custom manufacturing and testing: We are able to prepare custom Neomycin components for your unique specifications for use in cell culture, upstream biopharma manufacturing, or cancer research.  Additionally, we offer additional testing including endotoxin content, arsenic content, cell line testing, spectral analysis, and more. For more information, please contact us.

    Spectrum Neomycin is effective against certain Gram-negative and Gram-positive bacteria; however, Neomycin A is most likely less potent than standard grade Neomycin or Neomycin B.
    Cancer Applications Neomycin A, EvoPure® can be used to study its effects on tumor growth and angiogenesis.
    Molecular Formula C12H26N4O• xH2SO4

    Davis BD (1987)  Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev.  51(3):341-50

    Robertson JH (1971)  Antimicrobial activity of Neomycin C against Staphylococcus epidermidis. App. Micro. 22(6):1164-1165

    Tsuji K and Robertson JH (1969)  Comparative study of responses to Neomycins B and C by microbiological and gas-liquid chromatographic assay methods. App. Microbiol.  18(3):396-398

    Yuan L and Wei H (2006) Rapid analysis of native Neomycin components on a portable capillary electrophoresis system with potential gradient detection. Analytic. Bioanalyt. Chem. 385(8):1575-1579

    MIC Bacillus subtilis| 0.25 - ?| 1014| Enterobacter cloacae| >16 - ?| 1014| Erwinia carotovora| 4 - ?| 1014| Escherichia coli| 1 - ?| 1014| Proteus vulgaris| 0.25 - ?| 1014| Pseudomonas aeruginosa| >16 - ?| 1014| Pseudomonas solanacearum| 2 - ?| 1014| Staphylococcus aureus| 0.25 - ?| 1014| Xanthomonas axonopodis| >16 - ?| 1014| Xanthomonas oryzae| >16 - ?| 1014|