SKU: M093

    MycoRid™

    $52.50 - $367.50

    MycoRid™ Solution (1000x) is a highly stable, solubilized aqueous formulation of a polyene antifungal compound.  It is a substitute for Amphotericin B (Fungizone).  It has a lower level of cytotoxicity in cell culture due to the use of polysaccharide as a solubilizing agent, rather than sodium deoxycholate in Fungizone that has shown evidence of cytotoxicity in cell culture.  MycoRid can be stored up to 3 months at 4°C, unlike Amphotericin B solution that is stable for one month at 4°C.

    Mechanism of Action The active component of MycoRid™ Solution (1000x) has a similar mode of action to Amphotericin B (Fungizone). Polyene antimicrobials associate with membrane sterols in mammalian and fungal cell membranes and forms pores leading to essential ion leakage and ultimately, cell death.
    Spectrum MycoRid™ Solution (1000x) is active against fungal (molds and yeasts) cells and is not toxic to bacteria due to their lack of sterols. MycoRid™ is compatible with Pen-Strep solutions.
    Microbiology Applications MycoRid™ Solution (1000x) is used as an antimycotic selective agent in several routinely used selective media formulations to inhibit the growth of background fungal growth.
    References

    Brajtburg J, Powderly WG, Kobayashi GS and Medoff G (1990)  Amphotericin B: Current understanding of mechanisms of action. Antimicrob. Agents Chemother. 34(2):183-188  PMID 2183713

    Cleary JD, Rogers PD and Chapman SW (2003). Variability in polyene content and cellular toxicity among deoxycholate Amphotericin formulations. Pharmacother. 23(5):572-578  PMID 12741430

    Palumbo P et al (2010)  Effects of phosphatidylcholine and sodium deoxycholate on human primary adipocytes and fresh human adipose tissue. Int J Immunopathol Pharmacol. 23(2):481-489  PMID 20646343

    Perez-de-Luque A et al (2011)  Effect of amphotericin B nanodisks on plant fungal diseases. 68(1):67-74  PMID 21710554

    Rice LB, Louis B and Mahmoud A. Ghannoum MA (1999)  Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev.  501-17