Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria.
Kigamicin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Kigamicin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
