SKU: F023  / 
    CAS Number: 118974-02-0

    Fumitremorgin C

    $223.00 - $780.00
    Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.

    Fumitremorgin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    Mechanism of ActionRecent research has recognised fumitremorgin C as a potent and specific inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter.
    Molecular FormulaC22H25N3O3
    ReferencesPotent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Allen J.D. et al. Mol. Cancer Ther. 2002, 1, 417.

    Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Rabindran S.K. et al. Cancer Res. 2000, 60, 47.

    Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. Cui C.B. et al. J. Antibiot. 1996, 49, 527.

    Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage. Cole R.J. et al. J. Agric. Food Chem. 1977, 25, 826.