Ertapenem sodium, EvoPure® is a highly purified form of Ertapenem sodium. It is a broad-spectrum β-lactam carbapenem that interferes with peptidoglycan synthesis. Ertapenem sodium is soluble in water and sodium chloride.
|Mechanism of Action||β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.|
|Spectrum||Ertapenem sodium has broad-spectrum activity targeting a wide spectrum of aerobic and anaerobic Gram-positive and Gram-negative bacteria.|
|Microbiology Applications||Ertapenem sodium is commonly used in clinical in vitromicrobiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
For a complete list of ertapenem MIC values, click here.
|Molecular Formula||C22H24N3O7S • xNa (lot specific)|
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