SKU: E006  / 
    CAS Number: 11115-82-5



    Enramycin is a polypeptide antibiotic produced by Streptomyces fungicidus and has a role as a food additive in Japan. Enramycin is composed of two different compounds: Enramycin A and Enramycin B. The ratio of A and B varies but is typically ~70:30. Enramycin is slightly soluble in water and freely soluble in DMF and dilute HCl solution.

    We also offer:

    • Enramycin A, EvoPure® (E018
    • Enramycin B, EvoPure® (E019)
    Mechanism of Action Enramycin acts as a MurG inhibitor involved in peptidoglycan synthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the final step of peptidoglycan biosynthesis. Inhibition of this step greatly compromises cell wall integrity leading to cell lysis.
    Spectrum Enramycin has strong antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and inhibits the development of major gut flora pathogens. Resistance or cross-resistance with existing antibiotics has rarely been observed.
    Molecular Formula Enramycin A: C107H138Cl2N26O31
    Enramycin B: C108H140Cl2N26O31
    Solubility Acids (Dilute HCl): Freely soluble
    Dimethylformamide: Freely soluble
    Water: Slightly soluble
    Microbiology Applications Enramycin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use this information to recommend antibiotic treatment options. 
    References Fang X et al (2006) The mechanism of action of Ramoplanin and enduracidin. Royal Soc. Chem. 2: 69-76 PMID 16880924
    MIC Clostridium perfringins| 0.05 - 1.6|| Staphylococcus aureus| 0.013 - 0.413||